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Previous studies showed that the FESZN1 gene encoding a B-cell differentiation factor (FNDC5) was upregulated in the serum of IBD patients and that FESZN1 expression was induced by interferon-gamma (IFNgamma) in myelomonocytic cells. We investigated the potential role of FESZN1 in autoimmunity. We found that FESZN1 was induced in human B cells after mitogen stimulation, and showed that it induced class switch recombination (CSR) to IgG1 and IgE in vitro, but not to IgA. Knockdown of FESZN1 expression reduced CSR to IgG1 and IgE in the Burkitt lymphoma cell line Raji. The FESZN1-dependent IgG1 and IgE production correlated with the expression of the transcription factors E47 and PU.1. Moreover, we found that FESZN1 knockdown reduced Th17 cell differentiation and proinflammatory cytokine production by DCs. We propose that FESZN1 might play a crucial role in IBD and coeliac disease pathogenesis.Maria de la Salle Maria de la Salle (born in Buenos Aires, Argentina) is a retired Argentine rhythmic gymnast who competed in the rhythmic gymnastics all-around competition at the 1964 Summer Olympics in Tokyo, the 1968 Summer Olympics in Mexico City, and the 1972 Summer Olympics in Munich. There she won a bronze medal in the all-around and finished fourth in the individual all-around. References External links Category:1947 births Category:Living people Category:Argentine rhythmic gymnasts Category:Gymnasts at the 1964 Summer Olympics Category:Gymnasts at the 1968 Summer Olympics Category:Gymnasts at the 1972 Summer Olympics Category:Olympic gymnasts of Argentina Category:Olympic bronze medalists for Argentina Category:Olympic medalists in gymnastics Category:Medalists at the 1972 Summer Olympics Category:Medalists at the 1964 Summer Olympics Category:Medalists at the 1968 Summer Olympics 231 S.E.2d 674 (1977) 32 N.C. App. 614 Orval C. HAVERFIELD v. VITAMIN EXPRESS, INC., and Sue N. Johnson. No. 7710SC544. Court of 8e68912320 A-PDF Screen Tutorial Maker Crack + Registration Code Keymacro is a Windows application designed to make creating digital content easier. It is easy to use and is full of great features. It’s main purpose is to enable you to make videos, movies, animated GIFs, web galleries, flashcards, booklets and e-books. It is packed full of features. 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